Download Citation on ResearchGate | Antibacterial activity of Peganum harmala | Successive petroleum ether, chloroform and methanol extracts of Peganum. Successive petroleum ether, chloroform and methanol extracts of Peganum harmala seeds were tested (in vitro) for their antibacterial activity. examine the antibacterial activities of Peganum harmala extracts on the Key words: Antimicrobial effect, Biofilm, Peganum harmala, Pathogenic bacteria.

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Plant regeneration from hypocotyl culture of Peganum harmala. This plant has been considered for the treatment of a variety of human ailments, such as lumbago, asthma, colic, jaundice and as a stimulant emmenagogue Bukhari et al. In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral actigity acidic pHs.

Despite the numerous therapeutic properties, this plant has a great cytotoxicity. Journal List J Dent Shiraz v. So, may these extracts interfere with this pump and assumed as resistance modifying agents McKeegan et al. Conclusion Despite the remarkable antimicrobial effects of high concentrations of P. Based on the results from pH treatment Figure 7 Fig. In vitro assay for the anti-brucella activity of medicinal plants against tetracycline-resistant Br.

Our results indicate that crude extract of P. antinacterial

Moreover, the seed extract of P. Antimicrobial properties of Teucrium polium against some clinical pathogens.

Herbal therapy associated with antibiotic therapy: Among the evaluated different parts of P. In recent years, an explosive spread of MDR bacterial pathogens has become a serious concern worldwide in terms of public health and economic effects.


Among the evaluated parts of P. Table 1 The effect of ethanolic extract of P. Tested against Gram negative bacteria the obtained results were inconsistent. A review of current methods and implications for novel pharmaceuticals. Comparative study of 0. Colistin is an antibiotic that affects the cell membrane of bacteria. Abstract Statement of the Problem Dental caries is one the most prevalent diseases that affects humans throughout their lives.

Antibacterial effect of leaf part was moderate while stem and flower extracts showed relatively poor activity.

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wntibacterial There are various reports that P. Acute toxicological studies on the extract of Iraqi Peganum harmala in rats. Results of the synergistic effects of P. Agar diffusion technique was used to determine the antimicrobial effect of ethanolic extract of P.

Toxical effect of Peganum harmala L. It’s native to semi-arid rangeland, steppe area and sandy soils Mahmoodian et al. This plant is also used for diabetes, jaundice, asthma, dermatitis and many other illnesses.

In general, combination therapy such as one resulted from synergism between antibiotic and plant extract can be used to as pegaum choice for treatment of infections caused by MDR pathogens, to expand antibacterial spectrum, to prevent emergence of MDR pathogens and to minimize the possible toxic effects Aiyegoro et al.

Antibacterial effect and physicochemical properties of essential oil of Zataria multiflora Boiss. Peganum harmala can minimize Escherichia coli infection in poultry, but long-term feeding may induce side effects. Agar diffusion technique and micro broth dilution method were employed to test the antimicrobial effects of these two pfganum on S.


Gram positive bacterial species were Bacillus anthracisBacillus cereusBacillus pumilusStaphylococcus aureusPganum epidermidisListeria monocytogenes and Streptococcus pyogenes.

In conclusion, ethanolic extract of P. In general, the obtained results from TLC revealed that these antibacteroal parts of P. Antibacterial activity of the root extract against tested Bacillus species and S. TLC Thin Layer Chromatography results revealed that seed and root extracts were different in terms of nature and content of their constituents.

Despite the remarkable antimicrobial effects of high concentrations of P. The mean diameter of zones created by 0. Antibacterial activity of root extract of P. Conclusion In conclusion, among evaluated parts of P. Bergey’s manual pegxnum systematic bacteriology.

You are free to copy, sctivity and transmit the work, provided the original author and source are credited. Furthermore, the observed synergism of root extract with colistin against E.

MIC of extract on S. Combination of the root extract of P.

Antimicrobial Activity of Peganum Harmala L. on Streptococcus mutans Compared to % Chlorhexidine

As the incidence of dental caries is increasing in developing countries, it is very essential to apply new methods to decrease this disease. Some spots are more intensive in one extract comparing with other extract. In conclusion, among evaluated parts of P.

Asghari G, Lockwood GB.